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Wu Chenyao’s Paper Highly Cited among Top 1% in ESI

In recent days, the latest retrieval data from ESI have shown that an academic paper titled Design of injectable agar-based composite hydrogel for multi-mode tumor therapy was published in the journal Carbohydrate Polymers (2018,180:112-121) by Wu Chenyao, who was enrolled at USST to major in applied chemistry in the Department of Chemistry, College of Science in 2014. Until between November and December of last year, the number of the paper’s citations ranked in the top 1% in relevant areas. As a mainstream journal in the area of applied chemistry, the impact factor of Carbohydrate Polymers was 6.06 up to March in 2019.
Wu Chenyao worked with her teammates to design an injectable hydrogel by dissolving MoS2/Bi2S3-PEG (MBP), doxorubicin (DOX) and agar into water for the concurrent tumor photothermal and chemotherapy. As a minimally invasive tumor ablation method, photothermal therapy (PTT) has been intensively researched for the management of malignant tumors in recent years. Such a material design strategy is based on the phase-transformation of agar and is highly effective and versatile in treating malignant tumors. The formed solution was able to be intratumorally (I.T.) administered into a tumor at a relatively high temperature and automatically formed a hydrogel after cooling to body temperature. The resultant Agar/MBP/DOX (AMD) hydrogel can act as a macro-vessel to retain the MBP nanosheet and DOX and restrict their access to body fluid circulation. Moreover, AMD hydrogel did not compromise the photoacoustic and computed tomography imaging capacity, as well as the photothermal and chemotherapy efficiency of MBP nanosheets and DOX. The heat from the photothermal transformation of MBP nanosheet can promote drug-release from the hydrogel hus enabling an on-demand drug release. Furthermore, antibiotics were also able to be encapsulated in the hydrogel to avoid a potential wound infection during tumor surgery. This research provides the first demonstration that the combination of photothermal and chemotherapy with an in situ formed bio compatible hydrogel can lead to a high tumor-synergistic therapy and exert anti-relapse as well as anti-inflammatory effects simultaneously.
Wu Chenyao was enrolled into the Department of Chemistry, College of Science of USST, and was recommended for admission to East China Normal University for a master's degree in physical chemistry in 2018. During her study at USST, as an outstanding student representative she was cultivated under the scientific research practice program of the College of Science, she also joined in the relevant research group. Patiently guided by her supervisor Associate Professor Wang Shige, she scored impressive scientific achievements. Wu Chenyao's achievements in scientific research also fully reflect the implementation of scientific research practice plans for undergraduates and the idea of all-round talent training at USST.

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