February 17, 2023
| By SBC:An Yi | Copyedited by William, Zhang Liu
Recently, Dr. Muhammad Shemyal Nisar, one of SBC engineering lecturers, published an article as the joint first author titled “A 3D Biocompatible Plasmonic Tweezer for Single Cell Manipulation” on Small Methods (15.367, JCR-Q1). This study was posted by Materials Views China.
Plasmonic tweezers are an emerging research topic because of their low input power and wide operating range from homogeneous particles to complex biological objects. But it is still challenging for plasmonic tweezers to trap or manipulate objects of tens of microns, especially in biological science. This study introduces a new 3D biocompatible plasmonic tweezer for single living cell manipulation in solution.
The key design is a tapered tip whose three-layer surface structure consists of nanoprobe, gold nanofilm, and thermosensitive hydrogel, thiolated poly (N- isopropylacrylamide). Incident light excites the surface plasmon polaritons on gold film and generates heat to induce thermally driven phase transition of the thermosensitive hydrogel, which enables reversible binding between functionalized surface and cell membrane and avoids both thermal and mechanical stresses in the meanwhile. The 3D biocompatible plasmonic tweezer realizes selective capture, 3D pathway free transport, and position-controlled release of target cells, and it displays excellent biocompatibility, low energy consumption, and high operational flexibility.
Link to the paper: https://doi.org/10.1002/smtd.202201379