Recently, the Ultra-precision Optical Manufacture Innovation Team led by Academician Zhuang Songlin and Professor Zhang Dawei published a paper titled “Nanoagonist-mediated GSDME dependent Pyroptosis Remodels the Inflammatory Microenvironment for Tumor Phot-oimmunotherapy”in international top Journal Advance Functional Materials (IF:19.924). Dr.Zheng Lulu, and Fanyan from School of Optical-electrical and Computer Engineering and Wang Xiang from School of Materials Science were the first authors of the paper, professor Zhang Dawei and Dr. Li Yuhao were the corresponding authors.
Immunotherapy has always been an important means of medical treatment for cancer. Compared with traditional treatment methods, this research has activated the immune mechanism to the greatest extent, halted the occurrence of immune escape, and provided a subversive idea for tumor immunotherapy. The latest achievements were jointly made by USST, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and Changhao University, constructing a new drug carrying system of photoimmune nanomaterials which can change the inflammatory microenvironment of the tumor site by inducing cancer cells to scorch, enhance the degree of immune infiltration, activate the immune response of the body, and solve the problems of the failure of immunosuppressive agents at the immune checkpoint, providing a new method for the treatment of melanoma.
The strategy developed in this study could effectively restrain solid tumors via GSDME-mediated pyroptosis based on the non-invasive photocatalysis combined with DNA methyltransferase inhibitor, and eventually considerably improve the therapeutic performance of PD-1-negative cold tumors. These findings are expected to improve the clinical translation of photoimmunotherapy and address the ineffectiveness of checkpoint inhibitor immunotherapy in immunosuppressive cold tumors.
Advance Functional Materials is Firmly established as a top-tier materials science journal, cited in Nature, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week.
Link to the paper: https://onlinelibrary.wiley.com/doi/10.1002/adfm.202200811